The largest holder of Incyte stock is Baker Bros. Advisors LP, with 30.8 million shares (15.18% of the company), worth about $3.79 billion as of September 25, 2026. The 10 largest holders together own 50.9%.
In Q2 2026, 890 institutional holdings reports listed shares worth $23.20 billion.
Insiders reported 81 transactions in the last two years: 31 sales worth $41.65 million and no purchases. The newest one on file is from May 8, 2026 (Baker Bros Advisors L.P., Beneficial Owner of more than 10% of a Class of Security).
Major holders as of September 25, 2026; quarterly totals from institutional holdings reports (latest Q2 2026); insider transactions on file through May 8, 2026.

2026Q2
| Holder | Shares | % of company | Value |
|---|---|---|---|
| Baker Bros. Advisors LP | 30.8 million | 15.18% | $3.8B |
| BlackRock Advisors LLC | 13.6 million | 6.72% | $1.7B |
| Dodge & Cox | 12.0 million | 5.90% | $1.5B |
| Vanguard Capital Management LLC | 11.0 million | 5.44% | $1.4B |
| State Street Corporation | 9.7 million | 4.80% | $1.2B |
| Vanguard Portfolio Management LLC | 7.8 million | 3.84% | $960.0M |
| AQR Capital Management LLC | 5.3 million | 2.63% | $656.0M |
| Geode Capital Management LLC | 4.8 million | 2.34% | $585.0M |
| LSV Asset Management | 4.1 million | 2.03% | $508.0M |
| Invesco Advisers, Inc. | 4.1 million | 2.01% | $503.0M |
As of September 25, 2026.
| Quarter | Reports | Shares | Value |
|---|---|---|---|
| Q2 2026 | 890 | – | $23.2B |
| Q1 2026 | 847 | 204.0 million | $19.2B |
| Q4 2025 | 854 | 202.0 million | $19.9B |
| Q3 2025 | 748 | 199.0 million | $16.8B |
| Q2 2025 | 688 | 198.0 million | $13.5B |
| Q1 2025 | 658 | 190.0 million | $11.5B |
| Q4 2024 | 689 | 183.0 million | $12.6B |
| Q3 2024 | 633 | 185.0 million | $12.1B |
Shares and value held by institutions that file quarterly holdings reports (options not included).
| Insider | Date | Title | Transaction | Value |
|---|---|---|---|---|
| Baker Bros Advisors L.P. | May 8, 2026 | Beneficial Owner of more than 10% of a Class of Security | Conversion of Exercise of derivative security at price 84.53 per share. | $2.5M |
| Upadhyay Suketu P | May 4, 2026 | Chief Financial Officer | Stock Award(Grant) at price 0.00 per share. | – |
| Cagnoni Pablo J | Apr 17, 2026 | President | Conversion of Exercise of derivative security at price 64.25 - 71.93 per share. | $1.3M |
| Cagnoni Pablo J | Apr 17, 2026 | President | Sale at price 96.50 per share. | $1.8M |
| Meury William | Apr 15, 2026 | Chief Executive Officer | -- | – |
| Cagnoni Pablo J | Apr 15, 2026 | Officer | Stock Award(Grant) at price 0.00 per share. | – |
| Stein Steven H. | Apr 15, 2026 | Officer | Stock Award(Grant) at price 0.00 per share. | – |
| Harrigan Edmund P. M.D. | Mar 31, 2026 | Director | Stock Award(Grant) at price 94.12 per share. | $25,318 |
| Clancy Paul J. | Mar 31, 2026 | Director | Stock Award(Grant) at price 94.12 per share. | $24,942 |
| Baker Bros Advisors L.P. | Mar 31, 2026 | Beneficial Owner of more than 10% of a Class of Security | Stock Award(Grant) at price 0.00 per share. | – |
| Cagnoni Pablo J | Mar 17, 2026 | Officer | Conversion of Exercise of derivative security at price 61.18 - 64.25 per share. | $1.2M |
| Cagnoni Pablo J | Mar 17, 2026 | Officer | Sale at price 94.24 per share. | $1.8M |
Newest 12 of 81 insider transactions in the last two years.
Baker Bros. Advisors LP, with 15.18% of the company (as of September 25, 2026). Next: BlackRock Advisors LLC (6.72%) and Dodge & Cox (5.90%).
890 institutional holdings reports listed Incyte shares in Q2 2026 worth $23.20 billion.
In the last two years insiders reported 31 sales and no purchases (81 transactions in all); the newest on file is from May 8, 2026.