The largest holder of Apogee Therapeutics stock is Fidelity Management & Research Co. LLC, with 6.9 million shares (14.98% of the company), worth about $274.00 million as of November 8, 2025. The 10 largest holders together own 68.0%.
In Q2 2026, 68 institutional holdings reports listed 20.5 million shares worth $57.80 million.
Insiders reported 27 transactions in the last two years: 19 sales worth $6.33 million and 1 purchase. The newest one on file is from November 5, 2025 (Dambkowski Carl, Officer).
Major holders as of November 8, 2025; quarterly totals from institutional holdings reports (latest Q2 2026); insider transactions on file through November 5, 2025.

2026Q2
| Holder | Shares | % of company | Value |
|---|---|---|---|
| Fidelity Management & Research Co. LLC | 6.9 million | 14.98% | $274.0M |
| Wellington Management Co. LLP | 4.9 million | 10.59% | $194.0M |
| Wellington Trust Co., NA | 3.8 million | 8.25% | $151.0M |
| RTW Investments LP | 2.7 million | 5.88% | $108.0M |
| BlackRock Advisors LLC | 2.4 million | 5.24% | $96.0M |
| Driehaus Capital Management LLC | 2.3 million | 5.01% | $92.0M |
| Access Industries, Inc. (New York) | 2.2 million | 4.75% | $87.0M |
| Fairmount Funds Management LLC | 2.0 million | 4.44% | $81.0M |
| Fairmount Funds Management LLC | 2.0 million | 4.44% | $81.0M |
| Vanguard Fiduciary Trust Co. | 2.0 million | 4.37% | $80.0M |
As of November 8, 2025.
| Quarter | Reports | Shares | Value |
|---|---|---|---|
| Q2 2026 | 68 | 20.5 million | $57.8M |
| Q1 2026 | 41 | 11.9 million | $38.8M |
| Q4 2025 | 22 | 8.1 million | $24.5M |
| Q3 2025 | 13 | 805,000 | $2.3M |
| Q2 2025 | 10 | 102,000 | $199,000 |
| Q1 2025 | 7 | 68,100 | $92,600 |
| Q4 2024 | 11 | 149,000 | $304,000 |
| Q3 2024 | 6 | 24,300 | $60,200 |
Shares and value held by institutions that file quarterly holdings reports (options not included).
| Insider | Date | Title | Transaction | Value |
|---|---|---|---|---|
| Dambkowski Carl | Nov 5, 2025 | Officer | Sale at price 53.62 - 56.51 per share. | $593,903 |
| Dambkowski Carl | Nov 5, 2025 | Officer | Conversion of Exercise of derivative security at price 22.86 per share. | $184,252 |
| Dambkowski Carl | Oct 1, 2025 | Officer | Sale at price 39.80 per share. | $203,378 |
| Dambkowski Carl | Oct 1, 2025 | Officer | Conversion of Exercise of derivative security at price 22.86 per share. | $54,521 |
| Dambkowski Carl | Sep 3, 2025 | Officer | Sale at price 37.82 - 38.55 per share. | $103,198 |
| Dambkowski Carl | Aug 6, 2025 | Officer | Sale at price 37.78 per share. | $102,950 |
| Dambkowski Carl | Jul 2, 2025 | Officer | Sale at price 44.77 - 46.26 per share. | $454,954 |
| Dambkowski Carl | Jul 2, 2025 | Officer | Conversion of Exercise of derivative security at price 22.86 per share. | $168,364 |
| Dambkowski Carl | Jun 4, 2025 | Officer | Sale at price 36.96 per share. | $100,716 |
| Dambkowski Carl | May 7, 2025 | Officer | Sale at price 35.75 per share. | $97,419 |
| Dambkowski Carl | Apr 2, 2025 | Officer | Sale at price 35.56 - 37.59 per share. | $139,801 |
| Henderson Michael Thomas | Mar 5, 2025 | Chief Executive Officer | Sale at price 29.98 - 30.62 per share. | $301,511 |
Newest 12 of 27 insider transactions in the last two years.
Fidelity Management & Research Co. LLC, with 14.98% of the company (as of November 8, 2025). Next: Wellington Management Co. LLP (10.59%) and Wellington Trust Co., NA (8.25%).
68 institutional holdings reports listed Apogee Therapeutics shares in Q2 2026, 20.5 million shares in all worth $57.80 million.
In the last two years insiders reported 19 sales and 1 purchase (27 transactions in all); the newest on file is from November 5, 2025.