Krystal Biotech, Inc. (KRYS) Shareholders & Insider Trades
Krystal Biotech shareholders at a glance
The largest holder of Krystal Biotech stock is Fidelity Management & Research Co. LLC, with 4.4 million shares (14.93% of the company), worth about $1.59 billion as of September 25, 2026. The 10 largest holders together own 67.4%.
In Q2 2026, 450 institutional holdings reports listed shares worth $11.10 billion.
Insiders reported 30 transactions in the last two years: 18 sales worth $112.56 million and no purchases. The newest one on file is from March 4, 2026 (Krishnan Suma M, Officer, Director and Beneficial Owner).
Major holders as of September 25, 2026; quarterly totals from institutional holdings reports (latest Q2 2026); insider transactions on file through March 4, 2026.
Krystal Biotech, Inc.
Shareholders Summary
2026Q2
Ownership by Type
Geographic Distribution
Largest Krystal Biotech shareholders
| Holder | Shares | % of company | Value |
|---|---|---|---|
| Fidelity Management & Research Co. LLC | 4.4 million | 14.93% | $1.6B |
| BlackRock Advisors LLC | 4.0 million | 13.43% | $1.4B |
| Avoro Capital Advisor LLC | 2.9 million | 9.76% | $1.0B |
| Vanguard Portfolio Management LLC | 1.6 million | 5.32% | $566.0M |
| Krish S. Krishnan4.815 % | 1.4 million | 4.82% | $512.0M |
| Suma M. Krishnan4.572 % | 1.4 million | 4.57% | $486.0M |
| State Street Corporation | 1.4 million | 4.57% | $486.0M |
| Vanguard Capital Management LLC | 1.2 million | 4.19% | $446.0M |
| Soleus Capital Management LP | 939,254 | 3.17% | $338.0M |
| Capital Research & Management Co. (World Investors) | 777,843 | 2.63% | $280.0M |
As of September 25, 2026.
Krystal Biotech institutional holdings by quarter
| Quarter | Reports | Shares | Value |
|---|---|---|---|
| Q2 2026 | 450 | – | $11.1B |
| Q1 2026 | 385 | 28.4 million | $7.3B |
| Q4 2025 | 351 | 28.5 million | $7.0B |
| Q3 2025 | 307 | 28.3 million | $5.0B |
| Q2 2025 | 297 | 27.7 million | $3.8B |
| Q1 2025 | 322 | 27.7 million | $5.0B |
| Q4 2024 | 291 | 27.8 million | $4.4B |
| Q3 2024 | 310 | 28.4 million | $5.2B |
Shares and value held by institutions that file quarterly holdings reports (options not included).
Krystal Biotech insider trades
| Insider | Date | Title | Transaction | Value |
|---|---|---|---|---|
| Krishnan Suma M | Mar 4, 2026 | Officer, Director and Beneficial Owner | Sale at price 257.32 - 266.42 per share. | $6.6M |
| Krishnan Krish S | Mar 4, 2026 | Chief Executive Officer | Sale at price 257.31 - 266.56 per share. | $6.6M |
| Romano Kathryn | Mar 2, 2026 | Officer | Sale at price 267.60 per share. | $200,700 |
| Janney Daniel Spencer | Feb 27, 2026 | Director | Sale at price 275.45 - 276.17 per share. | $3.3M |
| Krishnan Suma M | Feb 27, 2026 | Officer, Director and Beneficial Owner | -- | – |
| Krishnan Krish S | Feb 27, 2026 | Chief Executive Officer | -- | – |
| Romano Kathryn | Feb 27, 2026 | Officer | -- | – |
| Janney Daniel Spencer | Feb 26, 2026 | Director | Sale at price 262.91 - 276.32 per share. | $16.1M |
| Janney Daniel Spencer | Feb 24, 2026 | Director | Conversion of Exercise of derivative security at price 2.46 per share. | $93,222 |
| Rossi Dino A | Feb 19, 2026 | Director | Sale at price 260.49 - 262.10 per share. | $5.0M |
| Rossi Dino A | Feb 19, 2026 | Director | Conversion of Exercise of derivative security at price 8.79 per share. | $166,570 |
| Romano Kathryn | Feb 9, 2026 | Officer | Sale at price 270.56 - 277.88 per share. | $3.4M |
Newest 12 of 30 insider transactions in the last two years.
Questions and answers
Who owns the most Krystal Biotech stock?
Fidelity Management & Research Co. LLC, with 14.93% of the company (as of September 25, 2026). Next: BlackRock Advisors LLC (13.43%) and Avoro Capital Advisor LLC (9.76%).
How many institutions own Krystal Biotech stock?
450 institutional holdings reports listed Krystal Biotech shares in Q2 2026 worth $11.10 billion.
Are Krystal Biotech insiders buying or selling the stock?
In the last two years insiders reported 18 sales and no purchases (30 transactions in all); the newest on file is from March 4, 2026.
