The largest holder of Exact Sciences stock is Fidelity Management & Research Co. LLC, with 26.9 million shares (14.48% of the company), worth about $1.47 billion as of November 8, 2025. The 10 largest holders together own 54.8%.
In Q2 2026, 2 institutional holdings reports listed 2,110 shares worth $216,000.
Insiders reported 46 transactions in the last two years: 7 sales worth $1.53 million and 1 purchase. The newest one on file is from November 4, 2025 (Baranick Brian, Officer).
Major holders as of November 8, 2025; quarterly totals from institutional holdings reports (latest Q2 2026); insider transactions on file through November 4, 2025.

2026Q2
| Holder | Shares | % of company | Value |
|---|---|---|---|
| Fidelity Management & Research Co. LLC | 26.9 million | 14.48% | $1.5B |
| Capital Research & Management Co. (World Investors) | 18.2 million | 9.80% | $996.0M |
| Vanguard Fiduciary Trust Co. | 16.7 million | 9.01% | $916.0M |
| Wellington Trust Co., NA | 12.0 million | 6.46% | $657.0M |
| BlackRock Advisors LLC | 8.9 million | 4.79% | $487.0M |
| State Street Corporation | 5.4 million | 2.90% | $294.0M |
| MFS Investment Management Canada Ltd. | 3.9 million | 2.10% | $214.0M |
| T. Rowe Price International Ltd. | 3.7 million | 1.99% | $203.0M |
| Geode Capital Management LLC | 3.2 million | 1.74% | $177.0M |
| Mackenzie Financial Corp. | 2.9 million | 1.54% | $156.0M |
As of November 8, 2025.
| Quarter | Reports | Shares | Value |
|---|---|---|---|
| Q2 2026 | 2 | 2,110 | $216,000 |
| Q1 2026 | 10 | 47,200 | $4.9M |
| Q4 2025 | 765 | 177.0 million | $17.9B |
| Q3 2025 | 613 | 179.0 million | $9.7B |
| Q2 2025 | 602 | 180.0 million | $9.5B |
| Q1 2025 | 601 | 184.0 million | $7.9B |
| Q4 2024 | 646 | 190.0 million | $10.6B |
| Q3 2024 | 651 | 190.0 million | $12.8B |
Shares and value held by institutions that file quarterly holdings reports (options not included).
| Insider | Date | Title | Transaction | Value |
|---|---|---|---|---|
| Baranick Brian | Nov 4, 2025 | Officer | Sale at price 70.08 per share. | $200,289 |
| Herriott James | Nov 4, 2025 | General Counsel | Sale at price 70.08 per share. | $105,120 |
| Zanotti Katherine S | Oct 24, 2025 | Director | Sale at price 65.00 per share. | $780,000 |
| Doyle James Edward | Oct 9, 2025 | Director | Sale at price 60.00 per share. | $120,000 |
| Herriott James | Oct 9, 2025 | General Counsel | Sale at price 60.00 per share. | $90,000 |
| Doyle James Edward | Aug 13, 2025 | Director | Sale at price 42.02 per share. | $62,400 |
| Baranick Brian | Aug 5, 2025 | Officer | -- | – |
| Orville Jacob A | Aug 5, 2025 | Officer | -- | – |
| Zanotti Katherine S | Jun 13, 2025 | Director | Sale at price 53.20 per share. | $170,612 |
| Barber Michael J | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Popovits Kimberly J | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Doyle James Edward | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
Newest 12 of 46 insider transactions in the last two years.
Fidelity Management & Research Co. LLC, with 14.48% of the company (as of November 8, 2025). Next: Capital Research & Management Co. (World Investors) (9.80%) and Vanguard Fiduciary Trust Co. (9.01%).
2 institutional holdings reports listed Exact Sciences shares in Q2 2026, 2,110 shares in all worth $216,000.
In the last two years insiders reported 7 sales and 1 purchase (46 transactions in all); the newest on file is from November 4, 2025.