The largest holder of Tempus AI stock is Eric Lefkofsky20.75 %, with 36.4 million shares (20.75% of the company), worth about $2.30 billion as of September 25, 2026. The 10 largest holders together own 58.8%.
In Q2 2026, 168 institutional holdings reports listed 86.0 million shares worth $1.22 billion, up 1.7% in shares from Q1 2026.
Insiders reported 49 transactions in the last two years: 41 sales worth $163.49 million and no purchases. The newest one on file is from November 3, 2025 (Epstein David R, Director).
Major holders as of September 25, 2026; quarterly totals from institutional holdings reports (latest Q2 2026); insider transactions on file through November 3, 2025.

2026Q2
| Holder | Shares | % of company | Value |
|---|---|---|---|
| Eric Lefkofsky20.75 % | 36.4 million | 20.75% | $2.3B |
| Brad Keywell7.326 % | 12.8 million | 7.33% | $810.0M |
| ARK Investment Management LLC | 10.0 million | 5.71% | $632.0M |
| Baillie Gifford & Co. | 8.2 million | 4.67% | $516.0M |
| Red Sky, LLC | 8.1 million | 4.59% | $508.0M |
| BlackRock Advisors LLC | 7.3 million | 4.17% | $461.0M |
| SoftBank Capital Partners LLC | 5.4 million | 3.08% | $341.0M |
| JPMorgan Investment Management, Inc. | 5.0 million | 2.85% | $315.0M |
| Vanguard Capital Management LLC | 5.0 million | 2.84% | $314.0M |
| Vanguard Portfolio Management LLC | 4.9 million | 2.80% | $310.0M |
As of September 25, 2026.
| Quarter | Reports | Shares | Value |
|---|---|---|---|
| Q2 2026 | 168 | 86.0 million | $1.2B |
| Q1 2026 | 147 | 84.6 million | $540.0M |
| Q4 2025 | 136 | 83.0 million | $660.0M |
| Q3 2025 | 114 | 64.7 million | $422.0M |
| Q2 2025 | 110 | 60.6 million | $398.0M |
| Q1 2025 | 109 | 54.8 million | $192.0M |
| Q4 2024 | 112 | 51.6 million | $298.0M |
| Q3 2024 | 89 | 29.3 million | $162.0M |
Shares and value held by institutions that file quarterly holdings reports (options not included).
| Insider | Date | Title | Transaction | Value |
|---|---|---|---|---|
| Epstein David R | Nov 3, 2025 | Director | Sale at price 90.00 per share. | $33,300 |
| Fukushima Ryan | Nov 3, 2025 | Chief Operating Officer | Sale at price 87.24 - 89.64 per share. | $445,160 |
| Lefkofsky Eric Paul | Oct 28, 2025 | Chief Executive Officer | Sale at price 87.42 - 91.55 per share. | $29.6M |
| Fukushima Ryan | Oct 6, 2025 | Chief Operating Officer | Sale at price 90.84 - 92.96 per share. | $461,606 |
| Lefkofsky Eric Paul | Sep 25, 2025 | Chief Executive Officer | Sale at price 75.09 - 77.88 per share. | $25.5M |
| Epstein David R | Sep 2, 2025 | Director | Sale at price 73.64 per share. | $18,410 |
| Fukushima Ryan | Sep 2, 2025 | Chief Operating Officer | Sale at price 72.73 - 78.06 per share. | $758,028 |
| Lefkofsky Eric Paul | Aug 27, 2025 | Chief Executive Officer | Sale at price 72.89 - 75.47 per share. | $24.6M |
| Leonsis Theodore J | Aug 26, 2025 | Director | Sale at price 75.83 per share. | $1.5M |
| Lefkofsky Eric Paul | Aug 19, 2025 | Chief Executive Officer | Sale at price 74.63 - 75.61 per share. | $1.3M |
| Bartolucci Ryan M | Aug 19, 2025 | Officer | Sale at price 74.63 - 75.61 per share. | $142,141 |
| Fukushima Ryan | Aug 19, 2025 | Chief Operating Officer | Sale at price 74.63 - 75.61 per share. | $1.3M |
Newest 12 of 49 insider transactions in the last two years.
Eric Lefkofsky20.75 %, with 20.75% of the company (as of September 25, 2026). Next: Brad Keywell7.326 % (7.33%) and ARK Investment Management LLC (5.71%).
168 institutional holdings reports listed Tempus AI shares in Q2 2026, 86.0 million shares in all worth $1.22 billion.
In the last two years insiders reported 41 sales and no purchases (49 transactions in all); the newest on file is from November 3, 2025.