The largest holder of Vaxcyte stock is Fidelity Management & Research Co. LLC, with 20.9 million shares (14.01% of the company), worth about $1.27 billion as of September 25, 2026. The 10 largest holders together own 78.7%.
In Q2 2026, 359 institutional holdings reports listed shares worth $9.87 billion.
Insiders reported 50 transactions in the last two years: 14 sales worth $8.58 million and no purchases. The newest one on file is from August 29, 2025 (Cowan Elvia, Officer).
Major holders as of September 25, 2026; quarterly totals from institutional holdings reports (latest Q2 2026); insider transactions on file through August 29, 2025.

2026Q2
| Holder | Shares | % of company | Value |
|---|---|---|---|
| Fidelity Management & Research Co. LLC | 20.9 million | 14.01% | $1.3B |
| Janus Henderson Investors US LLC | 18.0 million | 12.12% | $1.1B |
| Janus Henderson Investors US LLC | 18.0 million | 12.07% | $1.1B |
| T. Rowe Price Investment Management, Inc. | 12.2 million | 8.20% | $741.0M |
| RA Capital Management LP | 11.5 million | 7.71% | $697.0M |
| BlackRock Advisors LLC | 11.3 million | 7.61% | $687.0M |
| Wellington Trust Co., NA | 7.0 million | 4.71% | $425.0M |
| Vanguard Portfolio Management LLC | 6.6 million | 4.43% | $400.0M |
| Vanguard Capital Management LLC | 6.3 million | 4.27% | $386.0M |
| State Street Corporation | 5.4 million | 3.60% | $325.0M |
As of September 25, 2026.
| Quarter | Reports | Shares | Value |
|---|---|---|---|
| Q2 2026 | 359 | – | $9.9B |
| Q1 2026 | 354 | 163.0 million | $9.4B |
| Q4 2025 | 311 | 154.0 million | $7.1B |
| Q3 2025 | 301 | 143.0 million | $5.2B |
| Q2 2025 | 313 | 151.0 million | $4.9B |
| Q1 2025 | 339 | 146.0 million | $5.9B |
| Q4 2024 | 351 | 141.0 million | $11.5B |
| Q3 2024 | 358 | 138.0 million | $15.8B |
Shares and value held by institutions that file quarterly holdings reports (options not included).
| Insider | Date | Title | Transaction | Value |
|---|---|---|---|---|
| Cowan Elvia | Aug 29, 2025 | Officer | Stock Award(Grant) at price 0.00 per share. | – |
| Drapeau Anne S | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Brandicourt Olivier | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Paya Carlos V | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Lukatch Heath Scott | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Gilbert Halley E | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Furey John P | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Loxam Teri | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Lee Jacks | Jun 12, 2025 | Director | Stock Award(Grant) at price 0.00 per share. | – |
| Lukatch Heath Scott | Apr 8, 2025 | Director | Conversion of Exercise of derivative security at price 16.00 - 21.49 per share. | $117,490 |
| Guggenhime Andrew | Apr 7, 2025 | President | Conversion of Exercise of derivative security at price 20.93 per share. | $99,983 |
| Pickering Grant E | Apr 4, 2025 | Chief Executive Officer | Conversion of Exercise of derivative security at price 5.35 - 20.93 per share. | $183,888 |
Newest 12 of 50 insider transactions in the last two years.
Fidelity Management & Research Co. LLC, with 14.01% of the company (as of September 25, 2026). Next: Janus Henderson Investors US LLC (12.12%) and Janus Henderson Investors US LLC (12.07%).
359 institutional holdings reports listed Vaxcyte shares in Q2 2026 worth $9.87 billion.
In the last two years insiders reported 14 sales and no purchases (50 transactions in all); the newest on file is from August 29, 2025.